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Hsp90 orchestrates transcriptional regulation by Hsf1 and cell wall remodelling by MAPK signalling during thermal adaptation in a pathogenic yeast.

Thermal adaptation is essential in all organisms.In yeasts, the heat shock response is commanded by the heat shock transcription factor Hsf1.Here we have integrated unbiased genetic screens with directed molecular dissection to demonstrate that multiple signalling cascades contribute to thermal adaptation in the pathogenic yeast Candida albicans.We

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Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in Alzheimer's disease and Parkinson's disease

Gargi Ganguly,1 Sasanka Chakrabarti,2 Uttara Chatterjee,1 Luciano Saso3 1Department of Pathology, Institute of Post Graduate Medical Education and Research, Kolkata, 2Department of Biochemistry, ICARE Institute of Medical Sciences and Research, Haldia, West Bengal, India; 3Department of Physiology and Pharmacology “Vittorio Erspamer”, S

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